OBS-LIVER-F4407Active studySynthetic mock data

Multi-modality surveillance of cirrhotic cohort

Time-to-HCC detection

Phase

Observational

Enrollment

612/800

77%

Sites

22

Readout

2027-12

Waterfall — best % change in target-lesion sum (OBS-LIVER-F4407)

Per-subject best response from baseline. Sorted descending. Reference lines at PR (-30%) and PD (+20%) thresholds.

CR (0)PR (0)SD (4)PD (0)
-100%-75%-50%-25%0%25%50%PR threshold -30%PD threshold +20%Kenji Tanaka (F4407-LIV-208) — 14.3% — Stable disease+144407-208Fatima Hassan (F4407-LIV-271) — 0.0% — Stable disease04407-271Theo Romano (F4407-LIV-302) — 0.0% — Stable disease04407-302Yuki Iversen (F4407-LIV-411) — 0.0% — Stable disease04407-411% change
4 subjects, sorted by best responseDrill into study →

Protocol summary

Sponsor
Vanq Population Health
Status
active
Start date
2023-11-01
Arms
1
Sites
22
Primary endpoint
Time-to-HCC detection

Endpoints assigned to this study

Subjects in OBS-LIVER-F4407

4 subjects with serial RECIST measurements

Featured subject

Kenji Tanaka · s-4407-208 · MRN 6026508

Open full subject record →

RECIST 1.1 — Target lesions

Serial measurements (mm) and per-visit response

Sum-of-diameters; % from baseline (PR ≤ -30%); % from nadir (PD ≥ +20% absolute ≥ 5 mm)

Best response: SD
LesionModality
Baseline2024-06-01
Q12024-09-01
Q22024-12-01
Q32025-03-01
Q42025-06-01

Liver segment 4 nodule

MRI1416182022
Sum of diametersmm1416182022
% from baseline0.0%+14.3%+28.6%+42.9%+57.1%
% from nadir0.0%+14.3%+28.6%+42.9%+57.1%
RECIST responseNESDSDSDPD

Non-target lesions

Per-visit qualitative status (presence / absence / equivocal / new)

LesionBaselineQ1Q2Q3Q4
Portal hypertensionpresentpresentpresentpresentpresent

Cohorts in OBS-LIVER-F4407

Cross-links