P1b-HCC-E0210Active studySynthetic mock data

Dose-finding TKI + checkpoint combo (HCC)

MTD / DLT-rate at cycle 2

Phase

Enrollment

22/48

46%

Sites

Readout

2026-04

Waterfall — best % change in target-lesion sum (P1b-HCC-E0210)

Per-subject best response from baseline. Sorted descending. Reference lines at PR (-30%) and PD (+20%) thresholds.

CR (0)PR (2)SD (1)PD (1)

4 subjects, sorted by best responseDrill into study →

Protocol summary

Endpoints assigned to this study

Subjects in P1b-HCC-E0210

4 subjects with serial RECIST measurements

s-0210-007

Lucas Bianchi

Arm A · 2 target lesions

s-0210-009

Mei Garcia

Arm B · 1 target lesions

s-0210-014

Antonio Romano

Arm B · 1 target lesions

s-0210-019

Rachel Bauer

Arm A · 1 target lesions

Featured subject

Lucas Bianchi · s-0210-007 · MRN 6024207

RECIST 1.1 — Target lesions

Serial measurements (mm) and per-visit response

Sum-of-diameters; % from baseline (PR ≤ -30%); % from nadir (PD ≥ +20% absolute ≥ 5 mm)

Best response: SD

Lesion	Modality	C1D12025-12-01	C2D12026-01-12	C3D12026-02-23	C4D12026-04-06
Liver segment 7 (HCC)	MRI	64	58	52	48
Liver segment 4	MRI	22	21	18	16
Sum of diameters	mm	86	79	70	64
% from baseline		0.0%	-8.1%	-18.6%	-25.6%
% from nadir		0.0%	0.0%	0.0%	0.0%
RECIST response		NE	SD	SD	SD

Non-target lesions

Per-visit qualitative status (presence / absence / equivocal / new)

Lesion	C1D1	C2D1	C3D1	C4D1

Cohorts in P1b-HCC-E0210

No cohorts defined yet.

Cross-links